Projection of power and events in clinical trials with a time-to-event outcome
Patrick Royston
Hub for Trials Methodology Research
MRC Clinical Trials Unit
and University College London
London, UK
[email protected]
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Friederike M.-S. Barthel
Oncology Research & Development
GlaxoSmithKline
Uxbridge, UK
[email protected]
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Abstract. In 2005, Barthel, Royston, and Babiker presented a menu-driven Stata
program under the generic name of ART (assessment of resources for trials) to
calculate sample size and power for complex clinical trial designs with a time-toevent
or binary outcome. In this article, we describe a Stata tool called ARTPEP,
which is intended to project the power and events of a trial with a time-to-event
outcome into the future given patient accrual figures so far and assumptions about
event rates and other defining parameters. ARTPEP has been designed to work
closely with the ART program and has an associated dialog box. We illustrate the
use of ARTPEP with data from a phase III trial in esophageal cancer.
View all articles by these authors:
Patrick Royston, Friederike M.-S. Barthel
View all articles with these keywords:
artpep, artbin, artsurv, artmenu, randomized controlled trial, time-to-event outcome, power, number of events, projection, ARTPEP, ART
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