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The Stata Journal
Volume 14 Number 2: pp. 407-417



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Stata command for calculating adverse event and efficacy stopping boundaries for phase II single-arm trials

Bryan M. Fellman
MD Anderson Cancer Center
Houston, TX
bmfellman@mdanderson.org
Abstract.  Many programs and functions in statistical packages focus on the final stage of clinical trials, that is, the data analysis. In this article, I aim to assist in the early stages of clinical trials, specifically, the design of phase II single-arm trials. I present the new command stopbound, which calculates stopping boundaries and operating characteristics based on monitoring an adverse event, efficacy, or an adverse event and efficacy.
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View all articles with these keywords: stopbound, Bayesian clinical trial design, adverse event, efficacy rate, futility, simulation, operating characteristic

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