Stata command for calculating adverse event and efficacy stopping boundaries for phase II single-arm trials
Abstract. Many programs and functions in statistical packages focus on the final
stage of clinical trials, that is, the data analysis. In this article, I aim to assist in the
early stages of clinical trials, specifically, the design of phase II single-arm trials.
I present the new command stopbound, which calculates stopping boundaries and
operating characteristics based on monitoring an adverse event, efficacy, or an
adverse event and efficacy.
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Bryan M. Fellman
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stopbound, Bayesian clinical trial design, adverse event, efficacy rate, futility, simulation, operating characteristic
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