Power and sample-size analysis for the Royston–Parmar combined test in clinical trials with a time-to-event outcome: Correction and program update
Patrick Royston
MRC Clinical Trials Unit
University College London
London, UK
[email protected]
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Abstract. The changes made to Royston (2018) and to power_ct are i) in section 2.4
(Sample-size calculation for the combined test), to replace ordinary
least-squares (OLS) regression using regress with grouped probit
regression using glm; ii) in section 4 (Examples), to revisit the
worked examples of sample-size estimation in light of the revised estimation
procedure; and iii) to update the help file entry for the option
n(numlist). The updated software is version 1.2.0.
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Patrick Royston
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power_ct, update, randomized controlled trial, time-to-event outcome, restricted mean survival time, log-rank test, Cox test, combined test, treatment effect, hypothesis testing, flexible parametric model
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